Active substance: Orlistat
Orlistat could be used abusively by patients with anorexia or bulimia nervosa. This medicine should not be used in these patients. See Interactions, Precautions.
Weight loss in obese patients with non-insulin-dependent diabetes was lower than in obese patients without diabetes.
Monitor thyroid function in patients with hypothyroidism and consider the need to adjust the dose of levothyroxine. See Interactions.
See Interactions, Contraindications. The coagulation parameters INR must be monitored. The use of orlistat without medical prescription is not recommended due to the absence of studies on pharmacokinetic interactions See Interactions.
Seizures have been reported in patients who used both treatments. Gastrointestinal side effects also limit the applicability of the results in clinical practice.
Therapy is regarded as a long-term necessity because weight regain invariably follows drug discontinuation. Sibutramine, the other drug approved both in the United States and Europe, is slightly more effective but has more serious side effects.
The new generation of antiobesity drugs will not be available in the near future. In addition, improving environmental and social factors and establishing community programs that promote healthy lifestyles remain essential to fostering healthier food choices and increasing physical activity.
Use of trade names is for identification only and does not imply endorsement by the US Department of Health and Human Services. References 1. CDC growth charts for the United States: methods and development.
Vital Health Stat. Health, United States,. Table 75: Overweight, obesity, and healthy weight among persons 20 years of age and over, by selected characteristics: 1960—1962 through —.
Table 76: Overweight among children and adolescents 6—19 years of age, by selected characteristics: 1963—1965 through —. Tjepkema M. Adult Obesity in Canada: measured height and weight.
Ottawa: Statistics Canada.
Cross-national comparison of environmental and policy correlates of obesity in Europe. Eur J Public Health.
Overweight and obesity in China.