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In addition, patients with previous withdrawal syndromes are more likely to have more medically complicated alcohol withdrawal symptoms.

This in turn leads to more profound withdrawal symptoms including anxiety, convulsions and neurotoxicity.

Important information

These adverse effects are believed to be due to the neurotoxic effects of repeated withdrawal from alcohol on aberrant neuronal plasticity and cortical damage.

Repeated periods of acute intoxication followed by acute detoxification has profound effects on the brain and is associated with an increased risk of seizures as well as cognitive deficits.

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  • The effects on the brain are similar to those seen in alcoholics who have been detoxified repeatedly but not as severe as in alcoholics who have no history of prior detox. Thus the acute withdrawal syndrome appears to be the most important factor in causing damage or impairment to brain function.


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    The brain regions most sensitive to harm from binge drinking are the amygdala and prefrontal cortex. The recommended and tolerable dosage of gabapentin in the literature is reported between 900 and 3600 mg per day 11.

    However the higher doses would have some adverse effects and not well tolerated by all patients which can cause treatment failure. Erdemoglu 13 also reported side effects of high dose gabapentin in 26.

    Treating Chronic Side Effects Associated with Gabapentin

    Patients reported no side effects and complications during gabapentin treatment and the drug was well tolerated. It is reported that symptom relief occurs during the titration period even before the maximal dose is achieved.

    In other studies the lower doses of gabapentin has also shown to be effective with low side effects and intolerance 17 - 22. These results are indicative of beneficiary results of low dose gabapentin, which accompanies with lower side effects, higher tolerance as well as lower costs of treatment.

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    Among previous studies, only one had a control group 14 and the others have evaluated the results only in one group. It is possible that other factors have role in treatment improvement beside gabapentin.

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