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ILLUSTRATIVE CASE

Secondary outcomes were changes in 3 other sexual function scales, the Hamilton Rating Scale for Depression, and measured hormone levels.

Investigators followed the women for 8 weeks, measuring outcomes at 2, and 8 weeks. Sildenafil is better than placebo Using an intention-to-treat analysis with the last measurement 2, or 8 weeks as the end-point, both the treatment and placebo groups experienced improvement in sexual function.

The sildenafil group improved more than the placebo group.

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On the Clinical Global Impression Scale 1 to 7, with higher scores indicating worse sexual function, sildenafil users went from a mean of 4.

The difference in mean change from baseline was 0. Using a more conservative analysis in which participants who did not return for the 8-week follow-up visit were assumed to have returned to baseline, the difference in mean change from baseline was smaller 0.

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  • Orgasmic function shows significant improvement The sexual function scales used as secondary outcomes provided more detail about which types of sexual dysfunction benefited from sildenafil.

    On all 3 scales, orgasmic function significantly favored sildenafil over placebo.


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    The primary outcome was part from baseline to end-point in the Clinical Global Influence Scale, a clinician-rated scale based on sergeant of patient symptoms that was like to evaluate sexual function.

    In the domains of desire, arousal, and pain disorders, small to moderate improvements were seen in both groups, with no statistically significant differences.

    Baseline levels of cortisone, estradiol, follicle-stimulating hormone, leuteinizing hormone, progesterone, prolactin, sex hormone-binding globulin, testosterone, thyroid-stimulating hormone, and thyroxine, were normal, with no differences between the sildenafil and placebo groups.

    No serious adverse events occurred, however, and the medication appears to have been well tolerated overall, despite relatively high rates of side effects.

    Participants in the intervention group used an average of 5 doses of sildenafil per 2-week interval, the same number as those in the placebo group.

    Medication Management

    Small treatment effect. Grapefruit juice: Grapefruit juice can increase the amount of sildenafil in your bloodstream. Do not drink grapefruit juice when taking this medication. Hearing problems: If you experience a sudden decrease or loss of hearing you should seek medical attention immediately.

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