Active substance: Doxycycline
This study was undertaken to determine the modulatory effect of doxycycline on staphylococcal superantigen-induced T-cell activation and cytokine production from human peripheral blood mononuclear cells PBMC. Doxycycline was purchased from Sigma St.
All other reagents were also from Sigma. Human PBMC were isolated by Ficoll-Hypaque density gradient centrifugation of heparinized blood from normal human donors. Cytokines and chemokines were measured by an enzyme-linked immunosorbent assay with cytokine- or chemokine-specific antibodies in accordance with the manufacturer's instructions 15.
Doxycycline, when present, was added simultaneously with the stimulating agent. A few weeks, he started noticing color change of all of his fingernails and lifting of the nail plates from the nail beds.
Physical exam shows subungual hemorrhage and onycholysis of the fingernails Figure 2. The nails are all affected distally; the proximal nails and nail folds remain normal.
He denies recent illness or travel. He takes doxycycline 100 mg twice daily for acne. He is otherwise healthy.
He runs track; the season started 1 month ago. Can you spot the rash? Diagnosis: Phototoxicity sunburn and photo-onycholysis secondary to doxycycline.
Case Discussion Tetracycline antibiotics are commonly used in dermatology.
Their anti-inflammatory properties and few serious side effects have made them the mainstay of oral treatment of acne. Additionally, they are effective in treating rosacea, cutaneous staphylococcal infections and several systemic infections.
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