Active substance: Hydroxyzine
Furthermore, the number of cases detected is not only a function of the frequency of drug use in that particular jurisdiction but also of the analytical procedures used by the investigating laboratory.
However, risperidone and pimozide are not detected by the screening procedures used in most postmortem toxicology laboratories, and their overdose occurrence is thus likely to be under-reported.
The relative safety of the atypical antipsychotics has been comprehensively reviewed elsewhere. Also, a review of 574 inquiries to the UK National Poisons Information Service over 9 months revealed no fatalities after overdoses of atypical antipsychotics.
Gardner et al 31 reported rapid recovery with the use of activated charcoal in a 29-year-old woman from an overdose of 1110 mg of olanzapine that was associated with initial tachypnea, tachycardia, unstable blood pressure and hypoxemia.
The findings of this review suggest an adverse outcome for patients often with pre-existing undetected physical pathology such as cardiovascular disease who take overdoses of multiple medications and do not receive intervention.
Olanzapine has a high volume of distribution i. After death, significant redistribution from liver to central blood specimens occurs, and the higher range of olanzapine concentrations in postmortem blood is consistently observed independent of any assay differences.
Higher concentrations are also observed in central heart blood specimens than in peripheral femoral blood specimens.
In only 1 case of our series 17 was an antemortem specimen available for comparison. The patient died approximately 2 hours after admission to hospital, and the postmortem olanzapine heart blood concentration was elevated 5-fold over the antemortem level.
Thus, because of olanzapine's instability in blood, sample concentrations should be measured as soon as possible after death. The significant variation in blood concentrations of olanzapine in clinical practice makes it difficult to interpret postmortem findings.MC wrote: You are the 2 very best urologists I can personally recommend the corticosteroid route for bad.
In many overdose situations, there is often limited information concerning concomitant medications that were recently prescribed but not necessarily taken at the time of overdose. Furthermore, in clinical practice, antipsychotics are frequently taken in conjunction with other drugs and at greater than recommended doses.